重组改构人肿瘤坏死因子治疗恶性胸腔积液疗效观察

Oberserveation on the therapeutic effect of rmh-TNF in treating malignant hydrothorax

目的 评价重组人改构肿瘤坏死因子(rmh-TNF)治疗恶性胸腔积液的疗效和不良反应.方法 38例恶性胸腔积液患者排尽胸水后,注入单药rmh-TNF 2×106 IU,2次/周,观察其疗效、生活质量和不良反应.结果 38例中完全缓解12例,部分缓解23例,无效3例,总有效率92%;不良反应发生率有发热76%(29/38),胸痛44%(17/38).结论 rmh-TNF局部治疗恶性胸腔积液疗效可靠,不良反应少,生活质量提高,是治疗恶性胸腔积液的有效药物,尤其是治疗因恶性胸腔积液不能耐受全身静脉化疗的患者.

Objective To evaluate the effect and side effect of recombinant mutant human tumour necrosis factor (rmh-TNF) in the treatment of malignant hydrothorax. Methods Thirty-eight patients with malignant hydrothorax were observed rmh-TNF 2×106 IU were injected intrapleurally after complete drainage, two times a week,until the malignant effusion no longer appeared,to observe the effect,quality of life and side effect.Results Among 38 patients with malignant hydrothorax,12 patients obtained complete response(CR),23 patients partial response (PR)and 3 patients no change (NC), the overall response rate was 92%. The adverse reactions were fever 76%(29/38), and chest pain 44%(17/38).Conclusions The rmh-TNF is effective with minor side effect in the treatment of malignant hydrothorax,improve the quality of life.Therefore it is a favorable treatment of choice,especilly to that who can't tolerant chemotherapy.