吉西他滨为主的联合方案治疗晚期乳腺癌临床观察

Clinical observation of gemcitabine based combination chemotherapy in advanced breast

目的 观察吉西他滨联合阿霉素或顺铂治疗晚期乳腺癌的疗效和不良反应.方法 晚期经病理确诊的乳腺癌患者45例,32例既往使用蒽环类治疗失败,予以吉西他滨联合顺铂(GP方案)化疗,13例未曾应用蒽环类治疗,予以吉西他滨联合阿霉素(GA方案)化疗,吉西他滨剂量1000 mg/m2,第1、8天,其他药物使用常规剂量,21 d为1个周期,2个周期后评价疗效,有效者为化疗4个周期以上.结果 45例患者中完全缓解(CR) 5例,部分缓解(PR)15例,稳定(SD)20例,进展(PD)5例,总有效率(CR+PR)为53.3%,不良反应主要为恶心、呕吐、脱发、骨髓抑制,但均可耐受.无化疗相关死亡病例.结论 吉西他滨为主的联合化疗方案治疗晚期乳腺癌疗效较好,不良反应可以耐受.

Objective To evaluate the efficacy and toxicity of gemcitabine based combination chemotherapy in patients with advanced breast cancer.Methods Forty-five patients with a pathologic diagnosis were enrolled in the study,patients previously failured to dariamycin-based chemotherapy received the regimen of gemcitabine plus cisplation(GP regimen),the others received gemcitabine plus doxorubicin(GA regimen), the patients were treated with gemcitabine 1000 mg/m2 infusion for 10 minutes on day 1,8. Other agents were treated with regular doses,the regimen was repeated every 21 days and the clinical response was assessed after two cycles.The effective patients recieved at least four cycles.Results CR 5 cases, PR 15 cases,SD 20 cases,PD 5 cases,the overall response rate was 44.4 %(20/45),the toxicities included myelosuppression,nausea,vomiting and alopecia,but they were tolerable, there was no death during treatment.Conclusions The regimen based on is effective in the treatment of patients with advanced breast cancer,and the toxicities are tolerable.