超敏C-反应蛋白与白细胞介素-6在2型糖尿病合并冠心病患者中的表达和关系

Correlationship between high sensitive C -reactive protein and interleukin -6 in patients with type 2 diabetes mellitus complicated with coronary artery disease

目的 探讨超敏C-反应蛋白(hs-CRP)、白细胞介素(IL)-6在2型糖尿病合并冠心病患者中的水平及其关系.方法 将2型糖尿病患者80例分为合并冠心病组(40例)和单纯糖尿病组(40例),另选40例为正常对照组.比较各组间血清hs-CRP、IL-6、血脂的水平.结果 2型糖尿病组hs-CRP、IL-6水平明显高于对照组(P<0.01);2型糖尿病合并冠心病组hs-CRP、IL-6水平明显高于单纯糖尿病组(P<0.01).结论 血清中的hs-CRP及IL-6 水平与2型糖尿病合并冠心病密切相关,二者可能发挥协同作用.

Objective To investigate the correlationship between high sensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)in patients with diabetes mellitus complicated with coronary artery disease. Methods Eighty patients with T2DM were divided into two groups:40 cases complicated with coronary artery disease,40 cases without coronary artery disease, and 40 healthy people as control group. The levels of serum hs-CRP, blood lipid and IL-6 were compared between patients of three groups.Results Levels of hs-CRP and IL-6 were significantly higher in patients with T2DM than those in control group(P<0.01);and were significantly higher in patients with coronary artery disease than those without coronary artery disease(P<0.01).Conclusions Levels of hs-CRP and IL-6 were significantly higher in patients with T2DM complicated with coronary artery disease, and the close correlationship between hs-CRP and IL-6 may contribute to the pathogenesis of this process.