异位妊娠药物治疗的疗效观察

Ectopic pregnancy efficacy of drug treatment

目的 寻找一种简单、有效、成功率高、不良反应小且不影响生育功能的药物治疗异位妊娠的方法.方法 本院249例异位妊娠患者,其中136例行保守治疗.按用药随机分为A组46例,氨甲蝶呤(MTX)50 mg/ml单次肌肉注射并口服米非司酮(Ru486);B组45例,MTX单次肌肉注射(50 mg/ml);C组45例,口服米非司酮.定期监测三组患者血β-人绒毛膜促性腺激素(β-HCG)水平及阴道B超监测包块情况.结果 治愈率A组97.8%,B组86.7%,C组88.9%,A组较B、C两组明显缩短血β-HCG降至正常所需的时间,减少住院日(P<0.01),B、C两组比较差异无统计学意义(P＞0.05).结论 甲氨蝶呤和米非司酮联合用药治疗异位妊娠降低了单独用药剂量,具有疗效高、疗程短、不良反应小的优点,值得临床推广应用.

Objective To find a simple, effective, high rate of success of small toxicity without affecting the reproductive function of drug treatment of ectopic pregnancy. Methods Two hundred and forty-nine cases of hospital patients with ectopic pregnancy, in which 136 treated conservatively. According to medication were randomly divided into group A (46 cases): methotrexate (MTX) 50 mg/ml single intramuscular injection and oral administration of mifepristone (Ru486);Group B (45 cases): MTX single intramuscular injection (50 mg/ml);Group C (45 cases): Mifepristone. regular monitoring of serum β-HCG levels and vaginal mass of B-monitored. Results The cure rate in group A was 97.8%,in group B was 86.7%, in group C was 88.9%. There was significantly reduced serum β-HCG dropped to normal time required to reduce the hospital stay in group A than that in group B,C(P<0.01),there was no significant difference between group B and group C (P>0.05). Conclusions The combination therapy with methotrexate and mifepristone treatment of ectopic pregnancy reduced the single dose, with high efficacy, short duration of side effects of the merits and is worth clinical application.