阿托伐他汀钙与阿司匹林联用对原发性高血压伴颈动脉粥样硬化患者血栓前状态的临床干预

Clinical intervention of atorvastatin-aspirin combined with prothrombotic state in essential hypertensive patients with carotid artery atherosclerosis

目的 观察阿托伐他汀钙与阿司匹林联用对原发性高血压伴颈动脉粥样硬化患者血栓前状态的临床干预.方法 选择60例原发性高血压伴颈动脉粥样硬化、血栓前状态分子标志物异常患者,在基础降压下随机分成两组.治疗组用阿托伐他汀钙10 mg和阿司匹林0.1 g,每日 1次,口服.对照组用阿司匹林0.1 g,每日1次,口服.治疗 4周后监测全部患者的血栓前状态分子标志物的变化,并对两组患者进行疗效对比.结果 治疗组患者治疗后的血栓前状态分子标志物的水平明显下降(P<0.05),对照组患者治疗后的血栓前状态分子标志物的水平明显下降(P<0.05),治疗组治疗前后变化值与对照组治疗前后的变化值下降更明显(P<0.05).结论 阿托伐他汀钙、阿司匹林联用对原发性高血压伴颈动脉粥样硬化患者血栓前状态的干预有显著疗效.

Objective To observe the clinical intervention of atorvastatin-aspirin combined with prothrombotic state in essential hypertensive patients with carotid artery atherosclerosis.Methods Sixty patients with abnormal molecular markers in prothrombotic state in essential hypertensive patients with carotid artery atherosclerosis were randomly divided into two groups,under the condition of lowering blood pressure basically.The treated group was given atorvastatin 10 mg and aspirin 0.1 g once daily, while control group was given aspirin 0.1 g once daily.The changes of molecular markers in all patients had been monitored after treatment for 4 weeks.The effects of therapy in the two groups were compared. Results The changes of molecular markers before and after treatment in the treated group were significantly decreased(P<0.05), and that in the control group were significantly decreased too(P<0.05). The decrease of the levels of markers in the treated group was much more than that of the control group(P<0.05). Conclusions The intervention of atorvastatin-aspirin combination on prothrombotic state in essential hypertensive patients with carotid artery atherosclerosis has obtained obvious effect.