α-硫辛酸对颅脑创伤患者脑损害的影响

Effects of α-lipoicacid on cerebral neurologic injuries in traumatic brain injury patients

目的 研究α-硫辛酸对颅脑创伤患者脑损害的影响.方法 将50例行急诊手术的颅脑创伤患者随机分为对照组和治疗组,每组25例.治疗组在麻醉前静脉给予α-硫辛酸600 mg,每天1次, 连用5 d.对照组静脉滴注等量生理盐水.分别于麻醉前、手术结束时及术后1、3、5 d采集患者颈内静脉血,检测血清S100β蛋白和神经元特异性烯醇化酶(NSE)水平;3个月后行哥拉斯预后(GOS)评分.结果 治疗组相同时间点血清NSE和S100β含量明显低于对照组(P＜0.05),治疗组GOS评分明显好于对照组(P＜0.05).结论 α-硫辛酸能显著降低颅脑创伤患者血清S100β蛋白和NSE水平,改善预后,对脑损伤有保护作用.

Objective To investigate the efficacy of α-lipoicacid on cerebral neurologic injuries in traumatic brain injury patients. Methods Thirty-six patients undergoing operation were randomly divided into two groups, control group(25 cases) and experiment group(25 cases). In experiment group 600 mg α-lipoicacid was given by intravenous injection before anesthesia induction, qd for 5 days, while in control group only equivalent of normal saline was administration. Blood samples were taken from intrajugular vein for determination of serum levels of S100β protein, neuron-specific enolase(NSE) at five time-points: before anesthesia, at the end of operation and postoperation 1 d, 3 d, 5 d. Glasgow outcome scale(GOS) of all patients were determined after 3 months of therapy. Results Compared with the control group, serum levels of S100β and NSE in the experiment group were decreased significantly(P<0.05). The GOS were significantly better in experiment group versus control group.Conclusions α-lipoicacid can attenuate cerebral neurologic injury in traumatic brain injury patients,and improve their outcome probably.