药物性肝病的CT表现与病理对照

CT characteristics of drug-induced liver disease correlated with pathology

目的:探讨药物性肝病的影像表现及其病理基础。方法:回顾性分析50例药物性肝病的临床、影像及病理资料,所有病例均行肝穿病理检查及腹部CT平扫和增强扫描。结果:50例药物性肝病的腹部CT扫描中48例出现异常,其中局灶性肝损害29例(58%),弥漫性肝脏损害14例(28%),肝硬化表现5例(10%);肝脏外形改变,表面欠光整30例(60%),左、右叶比例失调30例(60%),可合并脾大、脂肪肝等。病理表现呈多样性,有肝细胞变性、坏死,炎性细胞浸润,胆汁淤积/胆色素沉积,以及弥漫性再生结节等。50例患者平均住院(38.3±20.3)天,除1例自动出院外其余均好转出院,无恶化或死亡病例。结论:药物性肝病的影像表现与病理特点均具有一定特征,影像与病理一致性较好,但缺乏特异性。

Objective:To investigate the CT characteristics and pathology of drug-induced liver disease.Methods:Retrospectively analyzed the clinical,CT and pathology materials of 50 patients with drug-induced liver disease.All patients had pre-and post-enhanced abdominal CT scanning,and pathology obtained by needle puncture biopsy of liver.Results:Of the 50 patients with drug-induced liver disease,48 cases showed abnormal CT findings including focal liver lesion(29 cases,58%),diffuse liver damage(14 cases,28%),and cir...