P-selectin、VCAM-1和VEGF三种细胞因子标志物联合检测对冠心病的诊断价值探讨

Three cytokines markers of P-selectin,VCAM-1 and VEGF for diagnosis of coronary heart disease

目的探讨P-selectin、VCAM-1和VEGF三种细胞因子标志物对冠心病的诊断价值。方法使用流式细胞仪检测75例冠心病患者和80例健康对照组的P-selectin、VCAM-1和VEGF血清含量,用ROC曲线确定临界值并分析其对冠心病的诊断性能参数,以确定其临床诊断价值。结果冠心病患者P-selectin、VCAM-1和VEGF血清浓度水平在稳定型心绞痛患者组、不稳定型心绞痛患者组和急性心肌梗塞患者组之间差异均有显著意义(P<0.05);三项指标对冠心病诊断的cut-off值分别为9 855.2 ng/L、864.05 ng/L和94.55 ng/L,敏感性SE(%)分别为85.31%、84.03%和89.35%、特异性SP(%)分别83.84%、83.85%和92.56%,ROC曲线下面积(AUC)分别为0.942、0.931和0.947。结论血清P-selectin、VCAM-1和VEGF在冠心病的发生发展过程中起一定的作用,对冠心病的诊断和分层有一定的临床价值。

Objective To explore the value of three cytokine markers of P-selectin,VCAM-1 and VEGF on diagnosis of coronary artery disease.Methods P-selectin,VCAM-1 and VEGF serum levels in 75 cases with coronary heart disease and 80 control group were detected by using flow cytometry and made up the critical value and performance parameters for the diagnosis of coronary heart disease to determine clinical diagnosis by using ROC curve analysis.Results Coronary heart disease P-selectin,VCAM-1 and VEGF serum levels in pa...