1-正丁基环己醇实验室合成

Laboratory Synthesis of 1-n-Butylcyclohexanol

设计了1-溴正丁烷与金属镁反应制备格氏试剂,并将其与环己嗣反应合成1-正丁基环己醇的实验室合成方案,探讨了金属镁预处理、格氏试剂与环已嗣反应时间等实验条件对产率的影响.实验结果表明:金属镁预处理与否对产率的影响不大,格氏试剂与环已酮反应时间需50 min,产率约为50.0%,完成整个实验约需5 h.

Laboratory synthesis of 1-n-butylcyclohexanol was designed.The detail procedure was that Grignard reagent was prepared by 1-butane bromide reaction with Magnesium,and then 1-n-butyl-cyclo-hexanol was synthesized by the reaction of Grignard reagent prepared with cyclohexanone.The reaction conditions were investigated.The results show that the pretreatment of rod magnesium has little effect on the productivity,the optical reaction time of the Grignard reaction is 50 min with the corresponding yield being approximately 50.0%,and this experiment can be done in 5 h.