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S100A4基因与恶性肿瘤侵袭及转移关系的研究进展

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摘要 目前的研究已经证实,肿瘤的发生与演进是多因素协同参与、多基因共同作用、多阶段逐步发展的过程,这一过程涉及多种癌基因以及抑癌基因的异常改变。其中S100A4是一个被筛选出来的特异性蛋白,其与恶性肿瘤生物学行为、特别是侵袭与转移密切相关,并且与患者预后关系密切,是目前肿瘤研究的热点基因。。
出处 《临床军医杂志》 CAS 2010年第5期859-862,共4页 Clinical Journal of Medical Officers
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  • 1Humar B,Blair V,Charltion A.E-cadherin deficiency initiatesgastric signet-ring cell carcinoma in mice and man[].Cancer Research.2009
  • 2Mylona E,Giannopoulou I,Fasomytakis E,et al.The clinicopath-ologic and prognostic significance of CD44+/CD24 (-/low)andCD44-/CD24+tumor cells in invasive breast carcinomas[].Human Pathology.2008
  • 3Clark IM,Swingler TE,Sampieri CL,et al.The regulation of ma-trix metalloproteinases and their inhibitors[].International Journal of Biochemistry Cell Biology The.2008
  • 4Kimura EJ,Helfman DM.Characterization of the metastasis-asso-ciated protein.S100A4.Roles of calcium binding and dimeriza-tion in cellular localization and interaction with myosin[].Journal of Biological Chemistry.2003
  • 5Jeon CH,Kim HL,Park JH.Induction of S100A4, S100A6, and galectin-1 during the lineage commitment of CD4+CD8+ thymocyte cell line is suppressed by 2,3,7,8-tetrachlorodibenzo- p-dioxin[].Toxicology Letters.2009
  • 6Ambartsumian N,Grigorian M,Lukanidin E.Genetically modified mouse models to study the role of metasasis-promoting S100A4 (mts1) protein in metastatic mammary cancer[].Journal of Dairy Research.2005
  • 7Boye K,Grotter?d I,Aasheim HC, et al.Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genes[].International Journal of Cancer.2008
  • 8Saya H,Nagano O.Role of CD44-mediated signal in cancer invasion and metastasis[].Tanpakushitsu Kakusan Koso.2008
  • 9Malashkevich VN,Varney KM,Garrett SC, et al.Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA[].Biochemistry.2008
  • 10Rogers CJ,Colbert LH,Greiner JW,et al.Physical activity and cancer prevention:pathways and targets for intervention[].Sports Medicine.2008

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