帕瑞昔布钠超前镇痛对开腹胆囊切除术患者血清IL-6和IL-10的影响

Effects of preemptive analgesia with parecoxib in patients undergoing cholecystetomy on serum IL-6 and IL-10

目的 评价帕瑞昔布钠(Parecoxib)超前镇痛对患者围术期血浆白细胞介素-6(IL-6)、白细胞介素-10(IL-10)的影响.方法 拟在全麻下行开腹胆囊切除术患者60例,随机分为两组,每组30例: 对照组(C组)为布托啡诺术后镇痛组,试验组(P组)为帕瑞昔布钠超前镇痛复合布托啡诺术后镇痛组,于麻醉诱导前(T1)、术毕(T2)、术后6 h(T3)、术后12 h(T4)、术后24 h(T5)、术后48 h(T6)采右颈内静脉血,采用酶联免疫吸附法测定血浆IL-6、IL-10浓度.结果 P组T2～T4时IL-6水平升高(P＜0.05);与C组比较,P组围术期IL-6水平较低,T3～T4时IL-10较高(P＜0.05).结论 帕瑞昔布钠超前镇痛可下调患者血清IL-6水平而促进IL-10的分泌,具有良好的镇痛效应.

Objective To access the influences of preemptive analgesia with parecoxib combined with butorphanol on plasma interleukin(IL)-6 and IL-10 in patients undergoing cholecystetomy.Methods Sixty patients scheduled for elective cholecystectomy under general anesthesia were randomly divided into two groups,i.e.Group C(control group,n=30) treated with butorphanol and Group P(preemptive group,n=30) treated with preemptive parecoxib plus butorphanol.Venous blood was drawn before the induction of anesthesia(T1),immediately after the end of operation(T2),and 6-,12-,24-and 48-h after operation(T3,T4,T5,T6) for determination of plasma IL-6 and IL-10 levels.Results The concentration of plasma IL-6 was significantly increased at the time points of T2-T4 in Group P(P<0.05).Plasma level of IL-6 was significantly lower in Group P than in Group C during and after operation(P<0.05),while that of IL-10 was much higher in Group P than in Group C at the time points of T3 and T4(P<0.05).Conclusion Preemptive analgesia with parecoxib reduces the levels of IL-6 and increases the production of IL-10.It has a perfect analgesic effect.