多奈哌齐对老年人缺血性脑卒中后认知功能障碍疗效的观察

Therapeutic effect of donepzil on elderly cognitive impairment due to ischemic stroke

目的观察多奈哌齐治疗老年人缺血性脑卒中后认知功能障碍的临床疗效。方法将62例缺血性脑卒中后认知功能障碍患者随机分为治疗组和对照组各31例,治疗组给予多奈哌齐片5 mg,1次/晚,对照组给予尼莫地平片30 mg,3次/d,疗程均为12周。治疗前后采用简易智能精神状态量表(Mini-Mental State Examination,MMSE)及日常生活能力量表(Activity of Daily Living,ADL)评定疗效。结果两组MMSE比较,治疗组与对照组治疗8周评估时差异即有统计学意义(P<0.05);治疗12周后,治疗组的ADL评分显著高于对照组(P<0.05)。结论应用多奈哌齐治疗缺血性脑卒中后认知功能障碍患者可显著提高其MMSE及ADL评分,改善认知功能和生活能力,疗效优于尼莫地平。

Objective To observe the therapeutic effect of donepzil on elderly cognitive impairment due to ischemic stroke.Methods Sixty-two elderly patients of ischemic stroke combined with cognitive dysfunction were randomly divided into trial group and control group(n=31/group).The trial group was given 5 mg of donepezil tablets once every night,and the control group was given 30 mg of nimodipine tablets thrice per day.All the patients were treated for 12 weeks.Before and after treatment,Mini-Mental State Examination(MMSE) and Activities of Daily Living(ADL) scale were used to assess the efficacy.Results After 8 weeks'treatment,there was a significant difference in MMSE scoring between the trial group and the control group(P<0.05).After 12 weeks' treatment,ADL score was significantly higher in the trial group than in the control group(P<0.05).Conclusion Donepezil treatment,which is more effective than Nimodipine treatment,can significantly increase MMSE and ADL scoring in the patients of ischemic stroke combined with cognitive dysfunction,and therefore improve their cognitive function and life skills.