匹多莫德防治反复呼吸道感染55例临床疗效分析

Analysis on the clinical efficacy of pidotimod in the recurrent respiratory infections of 55 cases

目的探讨匹多莫德对反复呼吸道感染的临床疗效。方法 90例哮喘患儿随机分为治疗组55人,对照组35人,治疗组在对照组治疗的基础上,加用匹多莫德治疗2个月,治疗前后监测IL-16、免疫球蛋白及淋巴细胞亚群。结果与对照组比较,治疗组急性病程天数、上下呼吸道感染次数均少于对照组,差异均有统计学意义(P<0.05)。感染急性发作期CD3+、CD4+、CD4+/CD8+淋巴细胞亚群较缓解期显著下降,CD8+细胞明显升高,免疫球蛋白轻度降低,IL-16明显增高,匹多莫德治疗后三项指标均有明显改善。除IgG、IgM外,余均有统计学意义(P<0.05)。结论匹多莫德治疗反复呼吸道感染疗效显著。

Objective To evaluate the efficacy of Pidotimod in the recurrent respiratory infections of children.Methods 90 cases were randomly divided into 2 groups.observation group of 55 cases and control group of 35cases,everychild in the 2 groups had been given a routine treatment above all.The children of observation group were additionally treat with pidotimod for 2months,plasma levels of IL-16,immunoglobulin,T cell subsets were detected by Elisa or flow cytometry before and after treatment.All the children had been observed for 1 years.Results Compare the 2 groups,pidotimod group had been lowered on days of acute asthmatic episodes,frequency of respiratory infections and onset of asthma,during acute phase of children with asthma,the mean level of CD3+,CD4+,CD4+/CD8+ had been evidently and immunoglobulin had been lightly after treatment;While IL-16 had been evidently declined,there were significantly differences(P<0.05) in the concentration of 3 items after treatment.Conclusion The therapeutic effect of Pidotimod in the recurrent respiratory infections of children is safe and effective.It not only gain favourable adjust of immune function but also achieve anti-inflammatory object.