p16蛋白在卵巢子宫内膜异位症中的表达及临床意义

Expression of p16 in ovarian endometriosis and its clinical significance

目的探讨p16蛋白在卵巢子宫内膜异位症中的表达及临床意义。方法采用免疫组织化学的方法(S-P)检测p16蛋白在卵巢子宫内膜异位症及正常子宫内膜组织中的表达。结果 p16蛋白在卵巢子宫内膜异位症中的表达明显低于正常子宫内膜组织,差异有统计学意义(P<0.05)。在卵巢子宫内膜异位症中p16蛋白的表达与痛经、月经异常、不孕无明显关系,而与囊肿大小、异位内膜浸润深度及盆腔浸润情况关系密切,差异有统计学意义(P<0.05)。结论 p16蛋白与卵巢子宫内膜异位症的发生、发展关系密切。

Objective To investigate the presentation and the clinical significance of p16 protein in ovarian endometriosis.Methods The expression of p16 was detected by means of immunohistochemistry in 43 specimens from ovarian endometriosis and in 27 specimens from normal endometria.Results p16 in ovarian endometriosis was clearly lower than that in normal endometria with a statistical significance(P<0.05).The lower expression of p16 in ovarian endometriosis was not related to dysmenorrhea,abnormal menstruation and barrenness,but to the size of cysts,the depth of ectopic intimal imbibition and the imbibition condition in pelvic cavity(P<0.05).Conclusion p16 protein is closely related to the development of ovarian endometriosis.