罗格列酮联合二甲双胍治疗2型糖尿病对部分炎症因子及降糖作用的影响

Effects of Rosiglitazone puls metformin on serum high C reaction protein and IL-6 in type 2 diabetes mellitus

目的观察罗格列酮联合二甲双胍对2型糖尿病的降糖作用以及炎症因子的影响。方法 48例符合入选条件的患者接受罗格列酮联合二甲双胍12周治疗。治疗前后测定患者空腹血糖(FPG)、血清胰岛素(FINS)、血脂、糖化血红蛋白(HbA1c)、标准餐后2 h血糖(2hPPG)和胰岛素(2hPINS)、高敏C反应蛋白(hCRP)、白介素6(IL-6),采用HOMA2model公式评价胰岛素敏感性。结果 12周时FPG、HbA1c和CRP均较治疗前基线时下降,差异有统计学意义(P<0.05);IL-6下降水平无统计学差异;胰岛素抵抗指数(HOMA2IR)显著低于治疗前(P<0.05)。结论罗格列酮联合双胍类药物治疗2型糖尿病在有效降低血糖水平,提高胰岛素敏感性的同时,能降低血中hCRP水平,IL-6无改变。

Objective The study was to observed the effects of rosiglitazone plus metformin on serum high C reaction protein and IL-6 and the effect of insulin resistance in type 2 diabetes mellitus.Methods It takes a comparative study involving 48 cases who are suitable for this study.Patients accepted the rosiglitazone added metformin over a 12-week treatment.Fasting plasma glucose(FPG),serum insulin(FINS),glycosylated hemoglobin(HbA1c),postprandial 2 h(2hPPG) blood glucose,and insulin(2hpINS),C reaction protein and IL-6 were determined at the first and last day of this study.HOMA2model formula evaluation was used in testing insulin sensitivity.Results After a 12-weeks’ treatment,FPG,HbA1c and C reaction protein of patients were lower than those before at baseline respectively(P < 0.05).IL-6 were without significant statistical differences.Insulin resistance index(HOMA2IR) was lower after treatment(P < 0.05).Other the result of metabolic parameter has no statistical differences.Conclusion Rosiglitazone added biguanides combined treatment of type 2 diabetes are effective not only in reducing in blood glucose levels and improving insulin sensitivity,But also decreasing serum hCRP,IL-6 no has significant statistical differences.