2型糖尿病患者肺功能变化及相关因素初探

Pulmonary function in patients with type 2 diabetes mellitus and its related Factors

目的探讨2型糖尿病患者肺功能的变化并分析其影响因素。方法比较72例2型糖尿病患者(糖尿病组)和50例健康志愿者(对照组)的肺功能状况,同时对糖尿病组患者的肺功能变化进行多因素线性相关分析。结果糖尿病组肺活量(VC)、1秒钟用力呼气容积(FEV1)、用力肺活量(FVC)、肺一氧化碳弥散量(DLCO)以及单位肺泡容积的一氧化碳弥散量(DLCO/VA)均明显低于对照组(P<0.05或P<0.01);多因素线性回归分析表明,VC、FVC与病程、空腹血糖(FPG)、糖化血红蛋白(HbA1 c)、微血管并发症积分、胰岛素抵抗指数(HOMA-IR)、体质指数(BM I)无显著相关;FEV1与HbA1 c及微血管并发症积分呈显著负相关(P<0.05),DLCO与糖尿病病程及微血管并发症积分呈显著负相关(P<0.05或P<0.01)。结论 2型糖尿病患者存在以限制型为主的肺通气功能障碍和弥散功能障碍,肺脏也是糖尿病损伤的靶器官。

Objective To investigate the change of pulmonary function in type 2 diabetes and its related factors.Methods The pulmonary function of 72 type 2 diabetic patients and 50 healthy objects were measured.The related factors of type 2 diabetes mellitus were analysed with liner regression analysis.Results Compared with control group,vital capacity(VC),forced expiratory volume in first second(FEV1),forced vital capacity(FVC),diffusion capacity for carbon monoxide of lung(DLCO) and DLCO corrected by alveolar volume(DLCO/VA) were significantly decreased in the type 2 diabetic group.Liner regression analysis showed that FEV1 was negatively correlated with HbA1c and microangiopathy score,while DLCO was negatively correlated with the duration of type 2 diabetes mellitus and microangiopathy score.Conclusion Pulmonary function is reduced in type 2 diabetes.The lung may also be the target organ of the chronic pathologic changes of diabetes mellitus.