急性心肌梗死早期尿激酶静脉溶栓的临床研究

Therapeutic Effect of Thrombolytic Therapy with Urokinase on Acute Myocardial Infarction

目的观察急性心肌梗死(AMI)早期尿激酶静脉溶栓的临床疗效。方法 32例AMI患者早期给予尿激酶静脉溶栓治疗与55例AMI患者给予常规治疗,观察溶栓治疗患者的再通情况及其溶栓后24h内T波倒置对判定冠脉再通的意义。结果溶栓组与对照组溶栓开始时间距发病<6h的冠脉再通率分别为76.0%和16.4%,差异有统计学意义(P<0.05)。发病至开始溶栓时间越短,再通率越高。早期溶栓24h内T波倒置提示冠脉再通,早期T波倒置与冠脉再通率有明显相关性(P<0.01)。结论急性心肌梗死早期使用尿激酶溶栓治疗可提高AMI的疗效,降低病死率。ST-T改变和T波倒置具有判断闭塞冠脉再通的临床价值。

Objective To observe the effect of early acute myocardial infarction (AMI) with urokinase thrombolysis.Methods 32 cases of AMI patients with early intravenous thrombolytic therapy in patients with AMI and 55 cases of conventional therapy as control.Observation of thrombolytic therapy in patients with recanalization within 24 hours after thrombolysis and T wave inversion in determining the significance of coronary reperfusion.Results Thrombolysis group and the control group coronary reperfusion rates were 76.0% and 16.4% (P<0.05),onset the shorter the time to start thrombolysis,recanalization rate.Early thrombolysis within 24 hours T wave inversion indicates that coronary reperfusion,the early T wave inversion and the rate of coronary reperfusion significantly correlated (P<0.01).Conclusion Acute myocardial infarction using thrombolytic therapy can improve the efficacy of acute myocardial infarction and reduce mortality.ST-T changes and T wave inversion judge coronary recanalization with clinical value.