脑梗死患者行经皮血管成形并支架置入术后造影剂肾病的临床研究

A clinical study of contrast-induced nephropathy following percuyanecus transluminal angioplasty in patients with cerebral infarction

目的:探讨低渗非离子造影剂对行经皮血管成形并支架置入术的脑梗死患者肾功能的影响。方法:选择接受经皮血管成形并支架置入术的脑梗死患者115例,患者均应用低渗非离子造影剂。测定术前和术后1、2、3 d肾功能,分析低渗非离子造影剂对脑梗死患者肾功能的影响。结果:115例脑梗死患者经皮血管成形并支架置入术后发生造影剂肾病(CIN)20例,发生率为17.4%。平均造影剂剂量CIN组为(230±33)ml,非CIN组为(120±60)ml,两组比较差异有统计学意义(P<0.05)。应用造影剂201～250 ml组肌酐水平与100～150 ml组比较差异有统计学意义(P<0.05)。结论:脑梗死患者行经皮血管成形并支架置入术后造影剂肾病的发生率与造影剂剂量相关。

Objective: To analyze the effect of low osmolar nonionic contrast medium on renal function in patients with cerebral infarction following percuyanecus transluminal angioplasty.Methods: 115 patients with cerebral infarction who underwent percuyanecus transluminal angioplasty were enrolled.All patients received low osmolar nonionic contrast medium,and serum creatinine concentration were measured at baseline and on the 1st,2nd,and 3rd days after that,to observe the effect of the low osmolar nonionic contrast medium on the renal function in patients with cerebral infarction.Results: Contrast-induced nephropathy(CIN) occurred in 20 patients out of the 115 patients with an incidence of 17.4%.The average contrast dosimeter was(230±33) ml in CIN group and(120±60) ml in non-CIN group,and significant difference was found between the two groups(P <0.05),significant difference of serum creatinine was found between 201～250 ml group and 100～150 ml group.Conclusion:The incidence of contrast-induced nephropathy has the correlation with the dosimeter of the contrast medium for patients with cerebral infarction following percuyanecus transluminal angioplasty.