142例静脉血栓栓塞症患者中遗传性抗凝血酶缺陷症的研究

Study on the Hereditary AntithrombinDeficiency of 142 Cases with Venous Thromboembolism

目的研究遗传性抗凝血酶缺陷症在静脉血栓栓塞症中(VTE)的发病率以及与获得性易栓因素的关系。方法检测142例(VTE)患者的抗凝血酶活性及含量,明确遗传性抗凝血酶缺陷症的发病率;建立患者临床调查表,了解患者的获得性易栓因素,了解与遗传性抗凝血酶缺陷症密切相关的获得性易栓因素。结果在142例静脉血栓栓塞症患者中有8例遗传性抗凝血酶缺陷症。创伤、长期卧床因素可能是诱导遗传性抗凝血酶缺陷症发生VTE的主要获得性因素。结论遗传性抗凝血酶缺陷症可能在我国VTE患者中所占比例不高,防止各种类型的创伤和避免长时间制动是预防此类患者发生VTE的重要措施。

Objective To study the ratio of the hereditary antithrombin deficiency of 142 cases of venous thromboembolism(VTE),and discovery the relationship of the hereditary antithrombin deficiency and acquired thrombophilia factors.Methods Based on the detection of the activity and(or)antigen of antithrombin-(AT),we can calculate the ratio of the hereditary antithrombin-Ⅲ deficiency.Through the clinical questionnaire,we can obtain the features of corresponding acquired factors which are closely related to the hereditary antithrombin-Ⅲ deficiency.Results There are 8 cases attributed to the hereditary antithrombin deficiency in the 142 VTE patients.The trauma and long-term bedridden are the important impact factors which evoke the hereditary antithrombin deficiency patients falling VTE.Conclusion The incidence of hereditary antithrombin deficiency may be relatively low in the VTE patients.The preventions of trauma and long-term bedridden are the important measures which prevent the hereditary antithrombin deficiency patients from falling the VTE.