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ⅡA分泌型磷脂酶A2与消化系统肿瘤关系的研究进展 被引量：4

Advances in research on the relationship between secretory phospholipase A 2 group ⅡA and gastrointestinal cancer
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摘要 ⅡA分泌型磷脂酶A2(secretory phospholipase A2 groupⅡA,ⅡA sPLA2)是花生四稀酸代谢的关键酶。近年来研究显示,ⅡA sPLA2与消化系统肿瘤的发生、侵袭、转移及预后密切相关。本文对ⅡA sPLA 2的生物学特性及其与消化系统肿瘤之间的关系做一综述,为消化系统肿瘤的临床诊治提供一个新的参考指标。 Secretory phospholipase A 2 group ⅡA(ⅡA sPLA2) is a key enzyme in the metabolism of arachidonic acid.Recent studies have shown that ⅡA sPLA2 has a close relationship with the occurrence,invasion,metastasis and prognosis of gastrointestinal neoplasms.In this paper,we review the biological characteristics of ⅡA sPLA 2 and its relationship with gastrointestinal neoplasms in order to provide a new reference index for the clinical diagnosis and treatment of gastrointestinal tumors.
作者 陈晖 王承党
机构地区 福建医科大学附属第一医院消化内科
出处 《肿瘤》 CAS CSCD 北大核心 2010年第9期802-805,共4页 Tumor
基金 福建省卫生厅青年科研课题资助项目(编号:2009-2-20)
关键词 分泌型磷脂酶 消化系统肿瘤 关系 研究进展 PHOSPHOLIPASE A relationship research 转移及预后 生物学特性 花生四稀酸 临床诊治 参考指标 关键酶 侵袭 代谢 Diges t i ve sys t emne opl a sms Phosphol i pase s A Neopl asmi nvasi veness Pr og nosi s
分类号 R73 [医药卫生—肿瘤]
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参考文献1

  • 1Ritsuko Yanaru-Fujisawa M.D.,Takayuki Matsumoto M.D.,Yoji Kukita Ph.D.,Shotaro Nakamura M.D.,Takashi Yao M.D.,Kenshi Hayashi Ph.D.,Mitsuo Iida M.D.. Impact of Phospholipase A2 Group IIa Gene Polymorphism on Phenotypic Features of Patients with Familial Adenomatous Polyposis[J] 2007,Diseases of the Colon & Rectum(2):223～231

同被引文献34

  • 1赵久达,贺菊香,耿排力.PLA2GⅡA基因在胃癌组织的表达及意义[J].山东医药,2006,46(10):24-25. 被引量：5
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  • 8TRIBLER L, JENSEN L T, JORGENSEN K, et al. Increased ex- pression and activity of group IIA and X secretory phospholipase A2 in peritumoral versus central colon carcinoma tissue [ J]. Anti- cancer Res, 2007, 27(5A) : 3179 -3185.
  • 9GANESAN K, IVANAVA T, WU Y, et al. Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta - eate- nin/TCF target gene [ J ]. Cancer Res, 2008, 68 (11) : 4277 - 4286.
  • 10International agency for research on cancer. Schitosomes live flukes and helicobacter pylori. IARC monographs on the evaluation on carcinogenic risks to humans. Lyon: IARC, 1994.

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肿瘤
2010年 第9期

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