早期高压氧联合三磷酸胞苷二钠治疗新生儿缺氧缺血性脑病34例

Early hyperbaric oxygen and CTP in treatment of 34 cases of neonatal hypoxic ischemic encephalopathy

目的 通过对新生儿缺氧缺血性脑病(HIE)的治疗分析来探讨HIE的治疗方法,做到早治疗、早干预,以免造成神经系统不可逆性损害.方法 2006年7月至2009年6月共收治68例新生儿缺氧缺血性脑病患儿,随机分成两组,在综合治疗的基础上治疗组加用高压氧联合三磷酸胞苷二钠(CTP)治疗,测定神经系统后遗症发生情况、智商发育商数等.结果 治疗组在3、14、28 d时新生儿神经行为评分(NBNA)及总有效率均比对照组要高,差异有统计学意义(P﹤0.05).结论 高压氧及CTP联合治疗对新生儿缺血缺氧性脑病疗效显著.

Objective To discuss the effect of the hyperbaric oxygen combined with cytidine triphosphate disodium(CTP) treatment on HIE in ill childrens'neurological development so as to greatly improve the prognosis of HIE. Methods Sixty-eight cases with HIE were randomly divided into control group and treatment group. The control group was treated with routine therapy including supporting treatment. The treatment group was treated with hyperbaric oxygen and CTP after the treatment procedure,the clinical effects were compared between the two groups. Results The treatment group's NBNA score and effective rate were higher than those in the control group (P<0.05). Conclusions Hyperbaric oxygen combined with CTP in treating HIE is effective and safe.