血液灌流对重度急性有机磷中毒患者血脂的影响

Effect of hemoperfusion on the lipids in patients with serious acute organophosphorous pesticides poisoning

目的 探讨血液灌流(HP)对重度急性有机磷中毒(AOPP)患者血脂的影响,为HP治疗高脂血症提供理论根据.方法 将确诊为重度AOPP的120例患者随机分为两组,均给予清除毒物、解毒及对症支持等常规治疗,治疗组62例同时于入院后12 h内完成HP治疗.所有患者均于入院后立即采血,并于12 h后重新采血进行血脂分析检查.结果 治疗组总胆固醇、甘油三酯、低密度脂蛋白、脂蛋白(a)等指标明显下降,与治疗前及与对照组比较差异均有统计学意义(P＜0.05).结论 HP可明显降低重度AOPP患者的血脂水平,但是否可用于高脂血症的治疗,尚有待于进一步研究.

Objective To investigate the effects of hemoperfusion(HP) on the lipids in patients with serious acute organophosphorous pesticides poisoning(AOPP),and provide theoretical bases of HP on patients with hyperlipidemia. Methods One hundred and twenty patients with serious AOPP were divided into two groups,both of them were treated with the conventional therapy,such as eliminating poison,detoxify,allopathy and sustaining,etc. At the same time,62 patients in the treatment group were treated with HP for 1.5 to 4 hours within 12 hours. All patients,being in hospital,were exsanguinated immediately,and after 12 hours,were exsanguinated again for checking the levels of lipids together. Results The levels of totle cholesterol(TC),triglyceride(TG),low-density lipoprtein(LDL)and lipoprotein(a)[Lp(a)]in serum decreased in the treatment group,compared with the control group,the difference were significant (P<0.05).Conclusions HP could bring down the levels of TC,TG,LDL and Lp(a)in serum in patients with serious AOPP evidently,but the assured effect of HP on hyperlipidemia depends on further clinical studys.