186例甲型H1N1流感患者不同时期C反应蛋白及血白细胞检测分析

Examination of CRP and WBC of 186 cases of influenza A(H1N1) at different time points

目的探讨C反应蛋白(CRP)及血白细胞(WBC)计数在甲型H1N1流感患者不同时期的变化及其临床价值。方法检测186例甲型H1N1流感患者CRP水平、WBC及中性粒细胞比值(NE%)。结果 (1)186例患者中,106例病程≤48h患者CRP为(10.35±17.10)mg/L,WBC为(6.74±2.47)×109/L,NE%为(63.00±9.56)%;80例病程>48h患者CRP为(32.58±39.29)mg/L,WBC为(8.58±3.82)×109/L,NE%为(72.01±11.92)%。病程>48h组CRP、WBC及NE%均高于病程≤48h组,差异有统计学意义。(2)病程≤48h组中,CRP高于正常17例,WBC高于正常5例,NE%高于正常7例,CRP高于正常例数显著高于WBC及NE%高于正常例数,差异具有统计学意义;病程>48h组中,CRP高于正常35例,WBC高于正常20例,NE%高于正常23例,CRP高于正常例数显著高于WBC及NE%高于正常例数,差异具有统计学意义。结论判断是否合并有细菌感染,CRP较WBC及NE%更敏感;随着病程延长,甲型H1N1流感患者合并细菌感染的程度及例数均逐渐增加。

Objective To investigate the changes and clinical value of C-reactive protein(CRP) and WBC in 186 cases of influenza A(H1N1) at different time points.Methods The peripheral blood samples from 186 patients with influenza A(H1N1) were collected,and then their CRP,WBC and neutrophil percentage(NE%) were examined immediately.Results (1) Among 186 cases,the CRP of 106 cases with onset ≤48 h was(10.35±17.10)mg/L,WBC was(6.74±2.47)×109/L and NE% was(63.00±9.56)%;the CRP of 80 cases with onset >48 h was(32.58±39.29)mg/L,WBC was(8.58±3.82)×109/L,NE% was(72.01±11.92)%.The CRP,WBC and NE% in the cases with onset >48 h were all higher than those in group with onset ≤48 h and the differences was statistically significant.(2)The group with onset ≤48 h included 17 cases of CRP above normal,5 cases of WBC above normal and 7 cases of NE% above normal.The group with onset>48 h included 35 cases of CRP above normal,20 cases of WBC above normal and 23 cases of NE% above normal.In both groups,the cases of CRP above normal were significantly higher than those of WBC and NE% above normal.Conclusion CRP is more sensitive than WBC or NE% in judging whether a case of influenza A(H1N1) is of concurrent bacterial infection.Moreover,the severity of disease condition and number of the cases suffering from concurrent bacterial infection increase gradually following the extension of course of H1N1 influenza A(H1N1).