7-氮杂吲哚的合成

Study on synthetic method of 7-azaindole

目的研究医药中间体7-氮杂吲哚的合成方法。方法以2-氨基-3-甲基吡啶为起始原料,经与二碳酸二叔丁酯反应保护2位氨基,然后在丁基锂的作用下得到二锂盐,二锂盐在稀盐酸中闭环反应,得7-氮杂吲哚。结果反应总收率63%。结论合成路线设计合理,条件温和,收率较好。

OBJECTIVE To study the synthetic method of 7-azaindole. METHODS The synthetic process was started from 2-amino-3-methylpyridine,after amine protection,reaction with butyl lithum,cyclization in dilute hydrochloric acid to achieve 7-azaindole. RESULTS The total yield was 63% . CONCLUSION The method is rational and feasible.