摘要
目的合成以L-2,3-二氨基丙酸为支化基元的新型高密度氨基肽类树枝状化合物G1。方法以丙二酸二乙酯为起始原料,经缩合、氢化还原,再胺解得到母核。将支化基元L-2,3-二氨基丙酸通过活性酯与母核以酰胺键相连接。结果和结论合成了2个未见文献报道的新型高密度氨基肽类树枝状化合物,并经1HNMR、13CNMR、MS确证化学结构。
OBJECTIVE To synthesize new generation dendrimers with high-density amine groups.METHODS The dendritic core was synthesized from diethyl malonate and L-α,β-diaminopropionic acid used as branch unit was attached covalently on the core by amides bonds.RESULTS and CONCLUSION Two novel dendrimers 5 and 6 with high-density amine groups were synthesized and confirmed by 1HNMR,13CNMR and MS.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2010年第6期647-649,共3页
West China Journal of Pharmaceutical Sciences