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心肌肥厚和扩张型心肌病中的Notch信号通路 被引量：2

Notch Pathway in Cardiac Hypertrophy and Dilated Cardiomyopathy
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摘要 Notch信号通路在脊椎动物和无脊椎动物中高度保守。它对正常心血管系统的发育有重要作用。心肌肥厚是许多疾病发展的一个重要阶段,但是它的形成机制到现在还没有完全清楚。扩张型心肌病是一组由于基因缺陷、心肌细胞损伤、心肌组织浸润使心脏肌肉层直接受累的疾病,其临床表现主要为心脏增大、心律失常,最终发生心力衰竭。最近的研究揭示Notch很可能在在这些疾病进程中起到非常关键的保护作用。 Notch signaling is a highly conserved pathway in vertebrates and invertebrates.It plays an important role in the development of the cardiovascular system.Cardiac hypertrophy is an important stage during the development of many diseases,but its mechanism has still not fully been understood.Dilated cardiomyopathy is a genetic defect due to myocardial cell damage,myocardial infiltration.Its clinical manifestations were cardiac enlargement,arrhythmias and heart failure in the long run.Recent studies reveal Notch is likely to play protective role in the process of these diseases.
作者 甄一松 王晓建 惠汝太
机构地区 中国医学科学院阜外医院心血管相关基因与临床教育部重点实验室
出处 《中国分子心脏病学杂志》 CAS 2010年第6期370-373,共4页 Molecular Cardiology of China
基金 北京协和医学院CMB基金 国家自然科学基金(31000644)
关键词 NOTCH 信号通路 心肌肥厚 扩张型心肌病 Notch signaling Pathway Cardiac hypertrophy Dilated cardiomyoapthy
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献22

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  • 2Loomes KM,Taichman DB,Glover CLet al.Characterization of Notch receptor expression in the developing mammalian heart and liver. American Journal of Medical Genetics . 2002
  • 3Grego-Bessa J,Luna-Zurita L,del Monte Get al.Notch signaling is essential for ventricular chamber development. Developmental Cell . 2007
  • 4High FA,Epstein JA.The multifaceted role of Notch in cardiac development and disease. Nature Reviews Genetics . 2008
  • 5Sakata Y,Kamei CN,Nakagami Het al.Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proceedings of the National Academy of Sciences of the United States of America . 2002
  • 6Kokubo H,Miyagawa-Tomita S,Tomimatsu Het al.Targeted disruption of hesr2results in atrioventricular valve anomalies that leadto heart dysfunction. Circulation Research . 2004
  • 7Donovan J,Kordylewska A,Jan YN,et al.Tetralogy of fallot and other congenital heart defects in Hey2mutant mice. Current Biology . 2002
  • 8Xin M,Small EM,van Rooij Eet al.Essential roles of the bHLH transcription factor Hrt2in repression of atrial gene expression and maintenance of postnatal cardiac function. Proceedings of the National Academy of Sciences of the United States of America . 2007
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  • 10Liu Y,Yu M,Wu L,Chin MT.The bHLH transcription factor CHF1/Hey2regulates susceptibility to apoptosis and heart failure after pressure overload. American Journal of Physiology Heart and Circulatory Physiology . 2010

同被引文献51

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中国分子心脏病学杂志
2010年 第6期

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