摘要
HERG基因编码快速激活延迟整流钾通道的α亚单位,快速激活延迟整流钾电流在心脏复极过程中起着极其重要的作用,HERG基因的突变导致快速激活延迟整流钾电流的异常,并进一步引起第二型遗传性长QT综合征(LQT2)。随着研究方法的不断发展,人类对HERG基因突变引起LQT2的机制的了解越来越深刻,作者就此作一综述。
The human ether-a-go-go-related gene(HERG)encodes the pore-forming α-subunits of channels that conduct the rapid delayed rectifier K+ current(IKr),which is one of the most important membrane currents responsible for ventricular action potential repolarization.Mutations in HERG gene lead to the rapid delayed rectifier potassium current abnormal that cause type 2 long QT syndrome(LQT2)。With the continuous development of research methods,people makes a great progress in understanding the mechanisms of LQT2 induced by HERG gene mutations.
出处
《中国分子心脏病学杂志》
CAS
2010年第6期378-381,共4页
Molecular Cardiology of China
基金
国家自然科学基金(编号:81070151)
广东省自然科学基金(编号:9151008901000157)
第一批中国博士后科学基金特别资助(编号:200801246)
