阻塞性睡眠呼吸暂停与冠心病的相关性及临床特点

Clinical Analysis of Obstructive Sleep Apnea and Coronary Heart Disease

目的了解国人阻塞性睡眠呼吸暂停(OSA)患者中冠心病(CAD)的发生率,并探讨两者之间关系和临床特点。方法对2009年01月-2010年6月以胸痛待查入住阜外医院心内科五区行冠状动脉造影(CAG)的患者,进行多导睡眠呼吸监测,收集其临床资料和常规生化指标。结果 257例患者入选,无OSA组、轻度OSA、中度OSA和重度OSA中,经CAG确诊CAD的患者分别为44.6%:60.0%:70.5%:72.1%(P<0.01);Logistic回归分析,最低血氧饱和度与CAD的发生显著相关(P=0.024)。结论 CAD的发生率在OSA患者中明显增加,随着OSA的严重程度呈递增趋势;多元回归分析,OSA是冠心病的独立危险因素。

Objective To determine the incidence of coronary artery disease(CAD)in patients with obstructive sleep apnea(OSA),and to evaluate the clinical relationship between CAD and OSA.Methods Consecutive patients who underwent both Polysomnography and coronary angiography from January 2009 to June 2010 in our department were enrolled in the current study.The clinical characteristics were collected and blood samples were measured.Results 257 patients were included and divided into four groups according to the severity of OSA.The incidence of CAD were 44.6%:60.0%:70.5%:72.1%(P<0.01)in no OSA group,mild OSA group,moderate OSA group,and severe OSA group,respectively.In logistic regression analysis,minimal oxygen saturation was significantly correlated with CAD(P=0.024).Conclusions The incidence of CAD was significantly higher in OSA patients than no OSA patients,and had an increased trend with the severity of OSA.OSA is the independent risk factors.