摘要
目的研究虾青素保护活性氧(ROS)所致线粒体氧化损伤的作用。方法观察虾青素对过氧化氢系统氧化损伤线粒体中丙二醛(MDA)、一氧化氮、谷胱甘肽(GSH)含量和超氧化物歧化酶(SOD)与ATP酶(ATPase)活性的影响,探讨虾青素保护线粒体氧化损伤的作用。结果过氧化氢损伤后,线粒体中MDA和NO含量升高,GSH含量降低,SOD和ATPase活性降低。虾青素(1.0×10-7,1.0×10-6,1.0×10-5 mol/L)能显著降低H2O2引起的线粒体MDA和NO含量升高,抑制GSH减少,提高SOD和ATPase活性。结论虾青素在一定浓度范围内对活性氧所致的线粒体氧化损伤有保护作用。
Objective To investigate the protective effect of astaxanthin on oxidative damage to mitochondria induced by active oxygen.Methods In the damaged mitochondria induced by active oxygen from H2O2 system,the effects of astaxanthin on the contents of MDA,NO and GSH were determined and the activities of SOD and ATPase were measured in order to investigate the protective effect of astaxanthin on mitochondria injury.Results Astaxanthin(1.0×10-7,1.0×10-6,1.0×10-5 mol.L-1,respectively) reversed the increase of MDA,N...
出处
《食品与药品》
CAS
2010年第11期412-414,共3页
Food and Drug
关键词
虾青素
线粒体
氧化损伤
astaxanthin
mitochondria
oxidative damage
