血液光量子疗法对急性白血病患者输注血小板后产生相关抗体的影响

Effect of ultravriolet irradiation therapy on the production of plateletassociated antibodies in acute leukemia patients after platelet transfusion

目的探讨血液光量子疗法对急性白血病患者血小板输注后血小板相关抗体产生的影响。方法将74例血小板减少的急性白血病患者随机分为两组,治疗组采用血液光量子疗法进行血小板输注,对照组单纯行血小板输注。两组均采用酶联免疫吸附法(ELISA),在血小板输注前后定量测定血小板表面相关抗体(PAIgG和PAIgM);计数血小板,计算1、24小时血小板增值(CCI):观察其临床效果和非溶血性输血反应(NHFTR)。结果血小板输注前两组PAIgM及PAIgG值无显著性差异,输注后两组PAIgM无显著性差异,而治疗组PAIgG值明显低于对照组(P<0.05);两组的CCI 1小时无显著性差异,治疗组CCI 24小时和临床效果明显优于对照组(P<0.05);治疗组的NHFTR低于对照组(P<0.05),其临床效果优于对照组(P<0.05)。结论血液光量子疗法可减少血小板输注无效。

Objective To investigate the effect of ultraviolet irradiation and oxygenationUBIO) on platelet transfusion of acute leukemiaPatients.Methods Divide 74 platelet-reduced acuteleukemia patients into two groups with randomized allocation.Therapy group transfuses platelet with UBIO,and control troup only transfuses platelet.Wemensurate platelet-associated antibodyPAlgG and PAIgM) of the two groups before and after platelet transfusion with Enzyme-linked Immuno Sorbent AssayELISA),count platelet amount and calculate 1 and 24 hour corrected count increamentCCI),and observe clinical effect and non-hemolytic febrile reactionNHFTR).Results There is no significant difference in PAIgM and PAIgG between two groups before platelet transfusion.After transfusion,there is no significant difference in PAIgM between two groups,but PAIgG of therapy group is lower than control groupP<0.05).There is no differece in CCI 1h between two groups.CCI 24h and clinical effect of therapy group are better than control groupP<0.05),And NHFTR of therapy groupis lower than control groupP<0.05).Its clinical effect is better than control groupP<0.05). Conclusion UBIO can reducerefractoriness to platelet transfusion.