脑梗死患者血浆同型半胱氨酸变化及临床意义

The change and of plasma homocysteine concentrationin Patmats with cerebral infarction clinical significance

目的探讨脑梗死患者血浆同型半胱氨酸变化及临床意义。方法测定120例脑梗死患者及41例健康对照者的血浆同型半胱氨酸(hCy)、维生素B12(VitB12)和叶酸(FA)水平。结果脑梗死组的血浆hcy水平(17.15±4.63umo1/L)显著高于对照组(10.12±2.62umol/L),P<0.01;血浆hcy水平与FA和VitB12均呈负相关;男女患者之间hcy的差异有显著性(P<0.01);高血压脑梗死患者的hcy水平高于单纯脑梗死患者(P<0.01)。结论hcy是脑梗死的一个重要发病因素,血浆hcy水平与FA和VitB12均呈负相关,雌激素水平对血浆hcy也有影响,高hcy血症与高血压性脑梗死有关。

Objective To explore the change of plasma homocysteine concentration in Patientswith cerebral infarction and its clinical significance.Methods Plasma homocysteme,Vitamin B_(12) and Folic acid(FA)levels were determined in 120 patients with cerebral infarction and 41 healthycontrols.Results The level of plasmahey was markedly higher in cerebral infarction patients than that in conlrol group(17.15±463umol/L Vs 10.12±2.62umol/L).Hcy level was significantly nesativety correlated with both Vilamin B_(12) and FA.The concentrations in male cerebral infarction patients were higher than in female patients.And the concentrations in cerebral infarction patientswith hypertension were higher than the patients with out hypertension.Conelusion Homocysteine level is one of the important risk factorsin cerebral infarction,Hcy level was significantly negaatively correlated with both Vitamin B_(12) and FA.Estrogen levels have influence on homocysteine levels,and the homocysteine levels have relationship with hyprtension cerebral infarction.