我院2004-2005年临床分离不动杆菌属的分布和药敏分析

Analysis the distribution and susceptibility of clinical isolated of Acinetobacter spp.from 2004 to 2005

目的了解我院临床分离的不动杆菌属的感染率及耐药状况,为治疗该类细菌感染的抗菌药物选用提供依据。方法分析2004年1月1日至2005年12月31日我院不动杆菌属临床分离株的药敏试验资料,药敏试验采用Kirby-Bauer法进行。结果2年间共分离不动杆菌属菌株363株,全部分离自住院患者。不动杆菌属在非发酵革兰氏阴性杆菌中所占比例为35%-37%;其中鲍曼不动杆菌约占不动杆菌属总数的80%。不动杆菌属对亚胺培南、头孢哌酮-舒巴坦耐药率较低,对其他抗菌药物耐药率均较高,但因菌种不同而异。其中鲍曼不动杆菌对其抗菌药物的耐药率较高,其他不动杆菌的耐药率较低。结论不动杆菌属是最重要的非发酵革兰氏阴性杆菌之一,不动杆菌属对亚胺培南、头孢哌酮-舒巴坦等耐药率较低,可根据病情选用于不动杆菌所致感染;其他各类抗菌药物耐药程度高,宜根据药敏试验结果选用。

Objective To investigate the distribution and susceptibility of clinical isolates of Acinetobacter spp.in our hospital,in order to offer some useful imformation for the antimicrobial selection in clinical treatment.Methods Retrospectively analyze the antimicrobial susceptibility of clinical isolates of Acinetobacter spp.from 1 st January 2004 to31st December 2005 in our hospital,which were tested by Kirby-Bauer method.Results There were 363 Acinetobacter spp.clinical isolates in the two years,and all of them were isolated from hospitalized patients.The ratio of Acinetobacter spp.to nonfermentative gram-negative bacilli was 35%-37%.In Acinetobacter spp.,80% isolates were A.baumanii.Results of susceptibility test showed the resistance rates of the imipenem and cefoperazone-sulbactam were much lower than other tested antimicrobials,and the rates varied with the species.Generally,A.baumanii was more resistant than other species ofAcinetobacter spp.Conclusions Acinetobacter spp.was one of the most important gram-negative nonfermentative bacilli.Imipenem and cefoperazone-sulbactam were the most active agents against these bacteria,and could be used to treat the infection according to the clinical patterns.Other antimicrobials had lower activity should be used on the result of susceptibility test.