正常孕妇妊娠晚期和妊高征患者血小板参数的变化

The changes of pintelet parameters during late gestation in normal pregnant women and patients with pregnancy induced hypertension

目的了解正常孕妇妊娠晚期和妊高征患者血小板参数的变化,探讨其临床意义。方法采用日本光电MEK-6318K血液分析仪分别对正常孕妇(64例),妊高征患者(64例),对照组(正常体检妇女64例)血液标本进行血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT)测定,并比较各组间的差异。结果妊高征组和正常孕妇组的MPV、PDW显著高于对照组(P<0.01);妊高征组MPV、PDW明显高于正常孕妇组(P<0.05);妊高征组的PLT、PCT显著低于对照组(P<0.01)。结论妊高征患者由于血小板消耗和破坏增加,导致血小板减少,MPV、PDW明显增高,因此,检测血小板参数对预测妊高征的发生有一定参考意义。

Objective To study the changes and clinical meaning of platelet parameters during late gestation in normal pregnancy women and patients with pregnancy-induced hypertension(PIH).Method The four parameters of plate]et,Platelet count(PLT),mean platelet volume(MPV),platelet volume distr/but～onwidth(PDW),platelet cdt(PCT) were measured by MEK-6318K hematology analyzer in 64 patients with PIlL 64 normal pregnant women and 64 normal non-pregnantwomen.Results MPV and PDW were significantly higher during late gestation in normal pregnancy women and patients with PIH than that of control group(P<0.0l).MPV and PDW of patients with pregnancy-induced hypertension was higher than that of late gestation in normal pregnancy women(P<0.05).PLT and PC Tin the pregnancy induced hypertension syndrome were lower than the normal pregnancy group(P<0.05).In comparison with control group,PLT and PCT of patients with pregnancy-induced hypertension were significantly increase(P(0.01).There were no significant differences between normal pregnancy women group and control group in PLT and PCT(P>0.05).Conclusions Because of the increasing consumption and destruction in PLT of PIH,PLT of P1H is decreasing,MPV and PDW enlarge.There fore the detection of pintelet parameters is helpful for predicting PIH.