血清透明质酸水平对肝硬变诊断价值的研究

Correlation of serum hyaluronic acid levels with hepatic cirrhosis

目的:探讨血清内透明质酸(HA)含量变化与肝硬变的关系。方法:用放射免疫测定法检测94例肝硬变、105例各型病毒性肝炎和40例健康人的血清透明质酸含量变化,肝功能指标用常规病理学方法检测。结果:肝病患者血清内透明质酸含量均高于正常人,特别以失代偿期肝硬变组升高最明显,为正常人的14．4倍。血清HA含量变化与血清白蛋白,凝血酶原时间,γ-球蛋白,总胆红素均有显著相关性,与肝硬变病情程度也具有显著正相关。结论:血清透明质酸水平对肝硬变的诊断预后判断和病情监测有良好的参考价值。

Objective:To investingate the relationship of serum hyaluronic acid (HA) levels with hepatic cirrhosis. Methods:The levels of serum HA in 94 cases of hepatic cirrhosis,105 cases of various types of viral hepatitis, 40 cases of healthy volunteer were detected with radioimmunoassay. The indexes of liver function were measured with routine pathological methods. Results:The levels of serum HA in patients with hepatopathy were higher than those in healthy volunteers,especially in patients with hepatic cirrhosis at loss-compensation phase,the levels was 14. 4 times of those in healthy volunteers. The levels of serum HA were significantly correlated with serum albumin, prothrombin time,γ-globulin and total bilirubin, were also positive correlated with the state of hepatic cirrhosis. Conclusion:The levels of serum HA could be used for prognostic judgement and illness monitoring of hepatic cirrhosis.