急性冠脉综合征的炎症机制及他汀类药物的抗炎作用

Inflammatory mechanism of acute coronary syndrome and anti-inflammatiory effect of cerivastatin

目的:探讨急性冠脉综合征的炎症机制及他汀类调脂药物的抗炎作用。方法:测定健康对照组60名,稳定性心绞痛(SAP)44例,不稳定性心绞痛(UAP)53例和急性心肌梗死(AMI)36例患者血浆中的胆固醇(CHO)、甘油三酯(TG)和C反应蛋白(CRP)水平,服用他汀类调脂药物4周后重复测定上述指标。结果:UAP组和AMI组患者血浆中的CRP水平显著高于对照组和SAP组,各组间CHO和TG水平无显著差异。服用他汀类药物后,各组患者的CHO水平均显著下降,TG水平变化不明显,SAP组血浆CRP水平无明显变化,UAP和AMI组患者血浆CRP水平显著降低,但仍显著高于SAP组。结论:炎症反应参与了急性冠脉综合征的发病过程,他汀类药物具有降脂作用之外,还有重要的抗炎作用。

Objective: To explore the inflammatory mechanism of acute coronary syndrome and anti-inflammatiory effect of cerivastatin. Methods: Blood cholesterol (CHO), triglyceride (TG) and C-reactive protein (CRP) levels were measured in 60 healthy controls 44 patients with stable angina pectoris (SAP), 53 patients with angina pectoris (UAP), and 36 patients with acute myocardial infraction (AMI). All of the patients excepr controls were given cerivastatins, and the above indexes were repeated 4 weeks later Results: The levels of CRP in UAP and AMI groups were significantly higher than controls and SAP group. There was no signifieanr difference in CHO and TG levels between different groups. After treatment with cerivastatins, levels of CHO were lowered markedly in all three groups, and the levels of TG showed no marked change. There was no change in CRP in SAP group, while the levels of CRP in UAP and AMI groups were significantly decreased, though still higher than of SAP group. Conclusions: Inflammation participates in the pathogenesis of acute coronary syndrome and cerivastatins have important anti-inflammatiory effects besides lowering blood lipid.