摘要
目的建立山羊下颌骨牵张成骨实验动物模型,探讨注射式硫酸钙对牵张成骨的促进作用。方法手术截断14只山羊的单侧下颌骨并埋入骨牵张器后,随机分为A、B两组,A组山羊在牵张成骨的同时注射硫酸钙,B组山羊单纯牵张成骨,通过对比得出结论。结果14只山羊的下颌骨被成功牵张7mm,牵张间隙内新骨形成。X线、病理、生物力学检测结果显示A组山羊下颌骨的牵张间隙内有更多新骨形成,愈合后的抗压能力更强。结论注射式硫酸钙对牵张成骨有促进作用。即在相同的牵张成骨、骨骼愈合时间内,硫酸钙可以促进牵张间隙内更多的新骨形成,使愈合后骨骼的强度更大。
Objective To find a new method to promote distraction osteogenesis(DO) by implantation of injected calcium sulfate in goat mandible.Methods A total of 14 goats were divided into two groups.Mandibles of all goats were fractured and the distraction osteogenesis devices were applied.In group A(n=7),distraction gap tissue was injected with calcium sulfate powder suspended in 0.9%normal saline.In group B(n=7),distraction gap tissue was injected with only 0.9%normal saline.Results The mandibles of all goats were lengthened 7mm successfully,the newly formed bone in the distraction gap was found exactly.The radiography test,the pathology test and the biomechanics test show:the amount of newly formed bone was greater in the distraction gap of the group A than in the group B,and the consolidation of healed mandible of the group A was stronger than group B.Conclusions The application of injected calcium sulfate to distraction gap can promote distraction osteogenesis.
