摘要
目的:研究大鼠急性牙髓炎造成中枢致敏时三叉神经脊束核尾侧亚核(caudal part of spinaltrigeminal nucleus,Vc)内c-fos蛋白的变化情况。方法:建立大鼠急性牙髓炎模型,利用免疫组化实验检测不同时间点Vc核c-fos蛋白变化情况,采用单因素方差分析比较不同时间点的变化情况。结果:在封药后12h至24h,Vc核c-fos阳性神经元表达数目显著增多。结论:Vc内c-fos蛋白的变化时程与牙髓炎进展密切相关。
Objective: To study the change of c-fos protein in Vc under hyperalgesia induced by LPS-derived acute pulpitis.Methods: A rat acute pulpitis model was induced,the express of c-fos protein in Vc was screened by the means of immunoblot and the results were analysis by ANOVA.Result: The express of c-fos protein in Vc enhanced apparently at the time of 12h to 24h.Conclusion: The expression of c-fos protein in medulla corelated closely with the development of acute pulpitis.
出处
《中华老年口腔医学杂志》
2010年第6期321-323,331,共4页
Chinese Journal of Geriatric Dentistry
基金
国家自然科学基金(30772450)
北京市自然科学基金项目(7082086)
