纳洛酮在失血性休克复苏中与一氧化氮的关系

The role of nitric oxide and the change of NO level on hemorrhagic shock

目的探讨纳络酮(NLX)在失血性休克复苏中的作用及对一氧化氮(NO)含量的影响。方法 建立失血性休克动物模型;实验分休克复苏生理盐水组(NS)﹑休克复苏纳洛酮处理组(NLX)两组;检测休克前后及复苏后血浆中NO的变化。结果与失血性休克前相比,NS和NLX组在失血性休克后血浆NO均增加(<0.01);失血休克复苏期,NLX组较NS组血浆NO含量显著降低(<0.05);NAL组存活时间(109.5±22.2)min显著长于NS组(60.8±14)min((<0.01)。结论 NLX延长动物休克模型的存活时间,可能是通过降低血浆NO水平而起作用的。

Objective To explore the function of naloxone and to investigate the change of nitric oxide on hemorrhagic shock.Methods Hemorrhagic shock rabbits were prepared by withdrawing blood.Rabbits were divided in control group(NS)and naloxone treatmentgroup(NLX).Results The change of palsma NO levels of both groups were statistically significant higher after shock and resuscitation(P<0.01).Plasma NO concentration were significantly lower in the NAL treatment group than in the control group(P<0.01).The survival time of rabbits in NLX group(109.5?2.2)minutes was significantly longer than in NS group(60.8?4)minutes.Conclusions The plasma NO level have been upregulated on hemorrhagic shock.Naloxone can inhibit the increase of NO level after shock,prolong survival time of treated rabbits.