胶质细胞与中枢神经的损伤和再生

Glial cells and the injury and regeneration of central nervous systema

目的:认识中枢神经损伤后神经再生的阻抑因素,明确中枢神经损伤后及其修复与再生过程中胶质细胞的作用。资料来源:应用计算机检索Medline数据库1990-01/2004-10的相关文献,检索词为“GliaorNeuroglia”和“CentralNerveSystemRegeneration”,分别组合进行检索,限定文章语言种类为英文。同时计算机检索中国期刊全文数据库1990-01/2004-10的相关文献,检索词为“中枢神经系统,神经再生,神经组织蛋白质类”,限定文章语言种类为中文。资料选择:对资料进行初审,选取与目的有直接关系的文章,纳入标准为实验研究类文章,对是否应用了随机、盲法、对照等条件未作限制。对观察性文章、经验总结、个案报告等文献不予采用。资料提炼:共搜集到51篇关于神经胶质及对中枢神经损伤后再生影响的随机与未随机文献,11篇文章符合纳入标准。资料综合:11篇文献中有8篇研究了神经胶质细胞对中枢神经损伤后再生的抑制作用,3篇研究了消除这些抑制性因素的策略。结论:胶质细胞是中枢神经元再生微环境中的重要细胞基础,胶质瘢痕形成和髓鞘抑制性因子是中枢神经损伤后再生受限的重要原因,以胶质细胞为突破口、改善中枢再生的微环境将是中枢神经损伤修复的研究方向。

OBJECTIVE： To review the inhibitory factor of nerve regeneration of central nervous system （CNS） after trauma, and to make definite the function of glial cells in the process of repair and regeneration of CNS after trauma. DATA SOURCES： The relevant articles from January 1990 to October 2004 were searched for in Medline with the keywords ＂Glia or Neuroglia＂ and ＂Central Nerve System Regeneration＂ assembled respectively with the language limited to English. Meanwhile, the relevant articles wero searched for in China Journal Full-text Database and Wanfang database with the keywords ＂CNS, nerve regeneration, nerve tissue protein＂ from January 1990 to October 2004 with language limited to Chinese. STUDY SELECTION： The articles were selected firstly, and those had direct relation with purpose were collected. Inclusion criteria： ① Randomized controlled trial with single-blind, double-blind or non-blind method; ② The trial including parallel controlled group. Those repeated researches and Meta analysis were excluded. DATA EXTRACTION： Totally 30 original articles containing randomized or non-randomized trails related to glia and its influence on CNS injury were collected. Eleven articles were included according to the inclusion criteria. DATA SYNTHESIS： Eight of the 11 articles were about the inhibition of glial cells on CNS regeneration, and 3 articles about the strategy to eliminate the inhibitory factors. CONCLUSION： Glial cells are the important cell background in regeneration microenvironment of CNS. The glial scar and myelin inhibitory factors are the important reasons for the restriction of regeneration of CNS nerve cells. Thus, to meliorate the regeneration microenvironment of CNS by means of glial cells is the research direction of CNS nerve regeneration.