升主动脉缩窄鼠升主动脉瘤的扫描电镜观察

Scanning electron microscope observation of rat ascending aortic aneurysms induced by ascending aorta banding

目的:观察升主动脉缩窄鼠升主动脉瘤的形态特征,为动脉瘤的临床和实验研究提供资料。方法:以幼年Wistar大鼠制作升主动脉缩窄鼠动脉瘤模型,取出动脉瘤,用扫描电镜观察。结果:动脉瘤的弹力板出现肥大、断裂,弹力板间的弹力纤维广泛破坏;动脉瘤壁中有炎性细胞浸润;平滑肌细胞大部分萎缩或消失;动脉瘤内皮严重受损,部分动脉瘤壁中有红细胞浸润。结论: 动脉瘤存在超微结构的改变,提示以上形态学改变是动脉瘤发生的重要病理学基础。

To investigate the morphological features of ascending aortic aneurysms induced by ascending aorta banding, providing data for experimental and clinical research of aortic aneurysm. Methods： Aortic aneurysm rat model was induced by ascending aorta banding of young Wistar rats. The aortic aneurysms were removed and observed urider scanning electron microscope. Results： The elastic lamellas of aneurysms had hypertrophy and fragmentation; the walls of the ascending aorta aneurysms were infiltrated by the inflammatory cells; the elastic fibers among the elastic lamellas were widely destroyed; most of the smooth muscle cells were atrophied or vanished; the endothelia of the ascending aorta aneurysm were seriously destroyed; and the walls of some ascending aorta aneurysms were infiltrated by the erythrocytes. Conclusion： The ascending aorta aneurysm has ultrastructural changes, which is the important pathologic basis for the ascending aorta aneurysm.