摘要
目的比较不同抗菌药物对泛耐药鲍曼不动杆菌(PDR-AB)感染的疗效,为临床抗PDR-AB感染治疗提供有效方案和依据。方法回顾性分析20例PDR-AB严重感染患者的感染特点、抗菌药物选择及疗效。结果 20例PDR-AB感染患者均接受头孢哌酮-舒巴坦治疗,其中7例为大剂量(9～12g/d)单独治疗,13例分别联合米诺环素或左氧氟沙星治疗;平均疗程(13.3±5.3)d,临床有效率50.0%,细菌清除率35.0%。10例经上述治疗无效的患者中有5例改为注射硫酸多黏菌素E治疗,平均疗程(16.8±5.0)d,临床有效率80.0%,细菌清除率60.0%。20例患者总临床有效率70.0%,细菌清除率50.0%,病死率30.0%。结论头孢哌酮-舒巴坦大剂量应用或联合米诺环素对PDR-AB感染有一定疗效,是国内治疗PDR-AB感染的首选;多黏菌素E对PDR-AB感染的疗效也较好,可作为治疗PDR-AB感染的有效选择,但国内尚缺乏上市产品。
Objective To investigate the efficacy of different antibiotics for the treatment of pan-drug-resistant Acinetobacter baumannii(PDR-AB) infection.Methods The clinical characteristics,application of antibiotics and outcomes of 20 patients with severe PDR-AB infection were retrospectively analysed.Results Seven patients were treated with high-dose cefoperazone-sulbactam monotherapy(9 to 12 g/d),and the other 13 were managed with cefoperazone-sulbactam combined with levofloxacin or minocycline,with the mean cou...
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2011年第1期111-114,共4页
Journal of Shanghai Jiao tong University:Medical Science
关键词
泛耐药
鲍曼不动杆菌
感染
pan-drug-resistant
Acinetobacter baumannii
infection
