孟鲁司特对呼吸道合胞病毒毛细支气管炎患儿尿白三烯E_4的影响

Effects of Montelukast on Expression of Leukotriene E_4 in Urinary of Children with Respiratory Syncytial Virus Bronchiolitis

目的:探讨孟鲁司特对呼吸道合胞病毒(RSV)毛细支气管炎患儿尿白三烯E4(LTE4)的影响,并观察其临床效果。方法:40例鼻咽分泌物RSV抗原阳性患儿在综合治疗的基础上加用孟鲁司特4 mg,分别于治疗前后用ELISA法检测尿LTE4水平,并观察两组喘息缓解所需时间。另选30例健康儿童作为对照组。结果:治疗前孟鲁司特组和常规治疗组患儿尿LTE4水平均明显高于正常组(P<0.05);治疗后孟鲁司特组LTE4水平较常规治疗组显著下降(P<0.05),喘息缓解时间少于常规治疗组(P<0.05),但均高于正常组(P<0.05)。结论:孟鲁司特降低RSV毛细支气管炎患儿尿LTE4水平,降低喘息复发率。

Objective To investigate the clinical efficacy of montelukast(MK) on treatment of respiratory syncytial virus(RSV) bronchiolitis in children,and to record the expression change of leukotriene E4 in urinary.Methods The positive antigen of RSV were determined in nasopharyngeal secretion of80 infants.The routine treatment were given in 40 infants,and the other 40 infants were given MK with 4 mg additionally.The levels of urinary LTE4 before and after treatment were detected by Enzyme-linked immunosorbent assay,respectively.The relief time of asthma were recorded and compared,and 30 healthy infants were selected as control group.Results The urinary levels of LTE4 in MK group and routine treatment group were significantly higher than control group before treatment(P<0.05).The level of LTE4 and the relief time of asthma in MK group were significantly lower than those of routine treatment group after treatment(P<0.05),but both significantly higher than those of control group(P<0.05).Conclusion Montelukast could effectively decrease the urinary LTE4 level and the relapse rate of asthma in infants with RSV bronchiolitis.