摘要
目的:研究托莫西汀对哌甲酯治疗无效的注意缺陷多动障碍(ADHD)患儿的疗效和安全性。方法:对39例经哌甲酯治疗3~6个月无效的ADHD患儿给予托莫西汀治疗8周,分别于第4周和第8周采用Conners父母症状问卷评分评估其疗效和安全性。结果:托莫西汀治疗4周后,26例患儿症状得到缓解;8周后,28例患儿有效;Conners父母症状问卷评分品行、学习、心身障碍、冲动-多动、焦虑因子和多动指数均较治疗前明显降低(P<0.05)。结论:托莫西汀可用于哌甲酯治疗无效的ADHD患儿,其不良反应轻微,可耐受。
Objective To evaluate the clinical efficacy and safety of tomoxetine on childhood attention deficit hyperactivity disorder(ADHA) in children with ineffective treatment by methylphenidate.Methods Tomoxetine was administrated for 8 weeks in 39 patients with ADHA unresponsive to 3 to 6 months treatment of methylphenidate.Conner's parents symptom questionnaire(PSQ) was employed to evaluate the efficacy and safety of tomoxetine at 4 and 8 weeks.Results The clinical symptom was relieved in 26 patients with 4-week treatment of tomoxetine and in 28 patients with 8-week treatment.The scores in the subscales of Conner's PSQ were reduced significantly after treatment(P<0.05),including behavior scale,learning problem,psychosomatic problems,opposition-hyperactivity,anxious factor and hyperactivity scale.Conclusion Tomoxetine could be effectively and well tolerated used for treatment of childhood ADHD unresponsive to methylphenidate.
出处
《湖北医药学院学报》
CAS
2011年第6期597-599,共3页
Journal of Hubei University of Medicine
关键词
托莫西汀
ADHD
疗效
Tomoxetine
Attention deficit hyperactivity disorder
Efficacy