托莫西汀对哌甲酯治疗无效的注意缺陷多动障碍患儿的疗效和安全性分析

Efficacy and Safety of Tomoxetine on ADHD Children That Underwent Ineffective Treatment with Methylphenidate

目的:研究托莫西汀对哌甲酯治疗无效的注意缺陷多动障碍(ADHD)患儿的疗效和安全性。方法:对39例经哌甲酯治疗3～6个月无效的ADHD患儿给予托莫西汀治疗8周,分别于第4周和第8周采用Conners父母症状问卷评分评估其疗效和安全性。结果:托莫西汀治疗4周后,26例患儿症状得到缓解;8周后,28例患儿有效;Conners父母症状问卷评分品行、学习、心身障碍、冲动-多动、焦虑因子和多动指数均较治疗前明显降低(P<0.05)。结论:托莫西汀可用于哌甲酯治疗无效的ADHD患儿,其不良反应轻微,可耐受。

Objective To evaluate the clinical efficacy and safety of tomoxetine on childhood attention deficit hyperactivity disorder(ADHA) in children with ineffective treatment by methylphenidate.Methods Tomoxetine was administrated for 8 weeks in 39 patients with ADHA unresponsive to 3 to 6 months treatment of methylphenidate.Conner's parents symptom questionnaire(PSQ) was employed to evaluate the efficacy and safety of tomoxetine at 4 and 8 weeks.Results The clinical symptom was relieved in 26 patients with 4-week treatment of tomoxetine and in 28 patients with 8-week treatment.The scores in the subscales of Conner's PSQ were reduced significantly after treatment(P<0.05),including behavior scale,learning problem,psychosomatic problems,opposition-hyperactivity,anxious factor and hyperactivity scale.Conclusion Tomoxetine could be effectively and well tolerated used for treatment of childhood ADHD unresponsive to methylphenidate.