摘要肿瘤的发生发展与癌基因的活化及抑癌基因的失活密切相关早已得到公认.近年来,多种抑癌基因陆续被发现并明确其作用机制.2007年Rivera等在研究Wilms’瘤时发现了一个新的抑癌基因WTX(Wilms tumor gene on the X chromosome),该基因是第一次在X染色体上发现的直接作为肿瘤抑制因子的基因,并首次在《Science》上报道.
1Nam J. Yoo,S. Kim,Sug H. Lee.Mutational Analysis of WTX Gene in Wnt/ β-Catenin Pathway in Gastric, Colorectal, and Hepatocellular Carcinomas[J]. Digestive Diseases and Sciences . 2009 (5)
2SPREAFICO F,NOTARANGELO LD,SCHUMACHERRF,et al.Clinical and molecular description of a Wilmstumor in a patient with tuberous sclerosis complex. American Journal of Medical Genetics . 2011
3CHUNG N G,KIM M S,CHUNG Y Je,t al.Tumor sup-pressor WTX gene mutation is rare in acute leukemias. Leukemia and Lymphoma . 2008
8Ruteshouser EC,Robinson SM,Huff V.Wilms tumor genetics:mutations in WT1,WTX,and CTNNB1 account for only about one-third of tumors. Genes Chromosomes and Cancer . 2008
9Scheel SK,Porzner M,Pfeiffer Set al.Mutations in the WTX-gene are found in some high-grade microsatellite instable (MSI-H)colorectal cancers. BMC Cancer . 2010
10Jenkins ZA,van Kogelenberg M,Morgan Tet al.Germlinemutations in WTX cause a sclerosing skeletal dysplasia but do notpredispose to tumorigenesis. Nature Genetics . 2009
