肝豆状核变性患者血凝指标与血小板检测的临床意义

Detection and Significance of Blood Coagulation Parameter and Platelet Count Measurement in Patients with Hepato-Lenticular Degeneration

目的研究肝豆状核变性(HLD)患者的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)和血小板(PLT)的变化及意义。方法对128例HLD患者和40例正常对照组用血凝仪检测PT、APTT、TT、Fib;血球仪检测PLT;全自动生化分析仪检测丙氨酸氨基转移酶(ALT)和胆碱酯酶(CHE)。结果 HLD组与正常对照组比较,PT(s)20.91±8.18、APTT(s)49.21±15.85、TT(s)17.98±3.18均明显延长,ALT(U)73.59±72.38明显增高,但Fib(g/L)1.68±0.68、PLT(×109/L)58.71±33.23和CHE(U)4 934.61±2 161.81明显降低,两者比较差异有统计学意义(P<0.01)。结论 HLD患者的PLT和血凝指标均有异常,可从多方面评价HLD患者凝血功能。

Objective To explore the changes and significance of prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fib),thrombin time(TT) and platelet count(PLT) in patients with hepato-lenticular degeneration(HLD).Methods To detect and analyze the indexes of APTT,PT,Fib and TT by blood coagulation analyzer,PLT by Auto Counter,ALT and CHE by HITACHI 7020 automatic analyzer in the experimental group of patients with HLD(n=128) and the control group of healthy people(n=40).Results In patients with HLD,PT(20.91±8.18)s,APTT(49.21±15.85)s,TT(17.98±3.18)s and ALT(73.59±72.38)U significantly increased,but Fib(1.68±0.68)g/L,PLT(58.71±33.23)×109/L and CHE(4 934.61±2 161.81) U obviously descended,those patients indices showed the significant difference compared with normal control subjects(P<0.01).Conclusion The changes of PT,APTT,TT,Fib and PLT in patients with HLD are determined,these indices can be used to evaluate the function of blood coagulation.