磁共振灌注加权成像在评估急性脑梗死缺血半暗带中的价值

The Value of MR Perfusion Weighted Imaging in Evaluating the Ischemic Penumbra of Acute Cerebral Infarction

目的探讨rCBV、rCBF和rMTT在评估急性期脑梗死IP中的价值。方法对临床确诊的29例脑梗死患者行PWI及常规MRI检查。并从PWI上计算出rCBV、rCBF和rMTT值。结果①核心、内缘和外缘区的rCBV、rCBF低于镜像区,rMTT高于镜像区,有统计学差异(P<0.05),周围与镜像区无差异,rCBV、rCBF按核心→内缘→外缘→周围区顺序逐渐增高,rMTT逐渐缩短。②核心与内缘区、内缘与外缘区及外缘与周围区各参数无统计学差异(P>0.05);核心与周围区有统计学差异(P<0.05);外缘与周围区的P值=0.05;内缘的rCBV、rCBF明显低于周围区(P<0.05),而rMTT则无统计学差异(P>0.05)。③PWI得出的IP区域与溶栓治疗后复查结果基本一致。结论 PWI能有效地对急性期脑梗死IP进行评估,rCBV、rCBF及rMTr是有用的参数。

Objective explore the value of rCBV,rCBF and rMTT in evaluating the IP of acute cerebral infarction.Methods This study involved 29 acute cerebral infarction patients proved by histopathologic.PWI and conventional MRI were underwent on them preoperatively.The rCBV,rCBF and rMTT value of each region were calculated from the PWI data.Results①the rCBV,rCBF of core,inner edge and outer edge area is lower than the mirror region,rMTT is higher,all have significant difference(P <0.05),the surrounding area have no difference to mirror area,rCBV,rCBF is gradually increased in the order of core→inner edge→outer edge→surrounding area, rMTT is gradually shortened.②core and inner edge area,inner edge and outer edge area,outer edge and surrounding area have no significant difference in all parameters(P>0.05);core and surrounding area have significant difference(P<0.05);the P value of outer edge and surrounding area is 0.05;the rCBV,rCBF of inner edge were lower than surrounding area(P<0.05),but rMTT have no significant difference(P>0.05).③the result of IP region were obtained by PWI,is same to review results after thrombolytic therapy basically.Conclusion PWI can evaluate the IP of acute cerebral infarction effectively,rCBV,rCBF,and rMTT are useful parameters.