环氧合酶-2和VEGF在口腔鳞状细胞癌中的表达及其临床意义

Expression of COX-2 and VEGF in Human Oral Squamous Cell Carcinoma.

目的:研究口腔鳞状细胞癌组织中COX-2和VEGF的表达及其临床意义。方法:用链霉素亲生物素-过氧化酶免疫组织化学(SP)法检测40例口腔鳞状细胞癌组织中COX-2和VEGF的表达,分析COX-2和VEGF表达与临床病理参数的关系以及COX-2表达与VEGF表达的相关性。结果:COX-2表达阳性率为47.5%(19/40),VEGF表达阳性率为60%(24/40)。COX-2和VEGF的表达与口腔鳞状细胞癌患者的年龄、性别及组织分化程度无明显关系(P>0.05),与临床分期和淋巴结转移有关。Ⅲ期与Ⅰ、Ⅱ期比较,原发灶中COX-2和VEGF表达率有升高趋势(P<0.05)。有淋巴结转移者与无淋巴结转移者比较,原发灶中COX-2和VEGF表达率有升高趋势(P<0.05)。COX-2表达与VEGF的表达呈正相关,COX-2阳性组与COX-2阴性组比较,原发灶中VEGF的表达呈升高趋势(P<0.05)。结论:COX-2和VEGF的表达与口腔鳞状细胞癌的增殖、浸润和转移有关,COX-2可能通过诱导血管生成而促进肿瘤浸润、转移,检测口腔鳞状细胞癌中COX-2和VEGF的表达有助于临床诊断和治疗。

Objective： To explore the relationship between expression of COX- 2 and VEGF and progression as well as, metastases of oral squamous cell carcinoma. Methods ： The expression of COX - 2 and VEGF were detected in 40 oral squamous cell carcinoma patients by immunohistochemical staining. The relationship between expression of COX -2 and VEGF and progression as well as metastases of oral squamous cell carcinoma was evaluated. Results ： Among 40 cases of oral squamous cell carcinoma, 19 cases were positive for COX -2（47.5% ） , and 24 cases for VEGF（60% ） , respectively. The expression of COX - 2 and VEGF were closely correlated with stage and lymph node metastasis of oral squamous cell carcinoma（ P 〈 0.05 ）. Conclusion： COX -2 and VEGF were involved in progression and metastases of oral squamous cell carcinoma. The expression of COX -2 and VEGF will be helpful to the diagnosis and treatment of oral squamous cell carcinoma.