多焦视网膜电图检测糖尿病早期视功能的变化(英文)

Early changes of retinal function in diabetic patients detected by multifocal electroretinogram

目的:了解多焦视网膜电图(mfERG)在糖尿病患者早期视功能的变化规律。方法:将所有被检者分为正常对照组(33 例)、糖尿病无视网膜病变组(63 例)以及单纯期糖尿病视网膜病变组(43 例)。采用mfERG 对上述3 组进行检测,比较3 组mfERG 一阶反应N1 波与P1 波的潜伏期与反应密度。结果:在糖尿病无视网膜病变组中,N1 波与P1 波反应密度低于正常对照组,异常范围位于环1- 环3。其中P1 波反应密度在单纯期糖尿病视网膜病变组中进一步降低。N1 波与P1 波的潜伏期在糖尿病无视网膜病变组中的变化无统计学意义,在糖尿病视网膜病变组中延长,异常范围扩大到环4 与环5。结论:mfERG 在糖尿病视网膜病变出现之前已发生异常变化,且能够定量地反映随着病情的进展,视功能的损害程度及范围。

AIM： To investigate the early changes of retinal function in diabetic patients detected by multifocal electroretinogram （mfERG）. METHODS： The first-order kernel responses of mfERG were recorded from eyes of 33 normal control subjects, 63 diabetic patients without retinopathy and 43 diabetic patients with background retinopathy. The response densities and implicit times of N1 and P1 were compared among the control, diabetic patients without retinopathy and diabetic patients with retinopathy. RESULTS： The response densities of N1 and P1 in cen- tral 3 rings were reduced significantly in diabetic eyes with and without retinopathy. And the implicit times of N1 and P1 were delayed significantly only in diabetic eyes with retinopathy. CONCLUSION： mfERG can detect the early changes of retinal function quantitatively in diabetic patients. Analysis of response densities and implicit times of N1 and P1 can reflect the progress of local retinal dysfunction in diabetes.