电针合谷穴对单眼视神经离断家兔FERG的影响

Effect of electric needling at Hegu point on the FERG of rabbits with one optic nerve broken off

目的:探讨针灸影响视觉系统的效应及其机制,明确视神经中之离中纤维在针刺影响视觉功能过程中的作用。方法:制作单眼视神经离断家兔模型,切断视网膜与中枢的联系,但不损伤视网膜血循环,观察电针对双眼FERG的影响,采用双眼比较,观察其作用机制。结果:在切断视神经时下行调制视网膜的离中纤维也被切断,但手术前后之术眼以及非手术眼与术眼的ERG变化无统计学意义;针刺合谷穴后,术眼与非术眼的ERG均发生变化,且有共同的变化趋势,但变化幅度不同,非手术眼较之术眼ERG之a、b波峰潜时延长,振幅降低。结论:离中纤维在电针影响家兔FERG的过程中起到一定的作用,但针刺对FERG影响的主要途径不是通过中枢的下行性抑制,针刺可以通过影响离中纤维在有限程度上对视网膜产生影响。另外,在不存在离中纤维的作用的情况下,针刺效应依然存在,其机制可能还有另外的途径参与。

AIM： To study the mechanism and effect of acupuncture and moxibustion on optic system and to define the role of the center nerve among the optic nerve during the process that the acupuncture affects the visual function. METHODS： The rabbits models with one-eye optic nerve broken off were built by breaking the connection between retina and centrum but keeping the cycle of retinal blood. Then the effect of electrotherapy on the FERG of the double eyes was observed and the mechanism wasstudied by comparing the two eyes. RESULTS： The center nerve reaching down to control the retina was also be cut off when cutting the optic nerve. Both the FERG in the operated-eyes before after operation and that in the operated-eyes and in the control eyes changed with no statistical significance. After acupuncture at the Hegu point, both the FERG in the operated-eyes and the control eyes changed with the same trend, but the breadths of the changing were different： the ERG in the control eyes has longer time and lower swing of wave a or b than the that in the operated-eyes. CONCLUSION： The center nerve has certain effect during the process that the acupuncture affects the FERG of the rabbits, but the main way is not by the down restraint of the centrum, and acupuncture can affect the retina limitedly by affecting center nerve. Without the action of center nerve, the effect of acupuncture still exists, therefore the mechanism may involves other ways.