PTEN蛋白在肺癌中的表达及意义

The Expression of PTEN Protein in Human Lung Cancer and Its Significance

目的:探讨肺癌中PTEN蛋白表达与临床病理特征的关系。方法:应用免疫组织化学PV-9000通用型二步法检测65例肺癌组织、10例癌旁肺组织、8例肺良性病变组织中PTEN蛋白的表达情况。结果:PTEN蛋白在肺癌中的阳性表达率为49.23%(32/65),在癌旁肺组织阳性表达率为90%(9/10),在肺良性病变组织阳性表达率为100%(8/8),肺癌PTEN蛋白阳性表达率显著低于癌旁肺组织及肺良性病变组织(P<0.05)。PTEN蛋白表达与非小细胞肺癌的组织分化程度及有无淋巴结转移有关。结论:PTEN蛋白的表达缺失在肺癌发生中可能起重要作用,并可能影响肿瘤的分化和预后。

Objective ：To study the expression of PTEN protein in human lung cancer and its clinical pathological features. Methods ：Immunohistochemistry （PV-9000 Polymer Detection System For Immuno-Histological Staining） was used to detect the expressions of PTEN protein in 65 cases of lung cancer tissues,10 cases of adjacent tumor tissues and 8 cases of benign pulmonary disease tissues. Results ：The positive expression of PTEN protein was 49. 23% （32/65） in lung cancer tissue, 90%（9/10） in adjacent normal lung tissue samples and 100%（8/8） in benign pulmonary disease tissues. The positive rate of PTEN was significantly lower in lung cancer tissue than that either in adjacent normal lung tissue samples or in benign pulmonary disease tissues（P〈0.05）. The expression of PTEN protein was associated with differentiation grade and lymph node metastasis. Conclusion ：The absence of expression of PTEN protein in lung cancer tissue might play an important role in carcinogenesis of lung carcinoma, and might affect the differentiation of tumor and the prognosis.